Abstract: Friction and wear behaviors of denture base with different content of antibacterial agent were studied under dry sliding and artificial saliva lubricated condition. The friction and wear tests were performed on a UMT-2MT tribometer with a ball-on-disk configuration in reciprocating motion at room temperature with frequency of 2 Hz and load of 20 N. Friction coefficient of denture base increases with the increases of the content of antibacterial agent during dry sliding process, while the depth of the track decreases with the increases of the content of antibacterial agent. The worn surface of denture base with 0% antibacterial agent is characterized by the coexistence of adhesion and fatigue while the characteristic of fatigue wear was observed on the worn surface of denture base with 2% antibacterial agent. The content of antibacterial agent had slight effect on the friction coefficient and wear mechanism of denture base under artificial sal. iva lubricated condition, which may be associated with the presence of the water film adsorbed on the worn surface, while the depth of the track markedly decreased with the increases of content of the artificial agent. 2% antibacterial agent was a suitable dose for denture base.