mPEG-b-PLGA胶束薄膜的制备及其摩擦学行为研究

马静毅; 宋仕永; 徐慧平; 张平余

mPEG-b-PLGA胶束薄膜的制备及其摩擦学行为研究

马静毅^1,2,
宋仕永^1,3,4, ,,
徐慧平⁵,
张平余⁶

1.
1. 河南大学特种功能材料教育部重点实验室, 河南开封 475004
2.
2. 中国科学院兰州化学物理研究所固体润滑国家重点实验室, 甘肃兰州 730000
3.
2. 河南大学药物研究所,河南开封 475004
4.
3. 中国科学院兰州化学物理研究所固体润滑国家重点实验室, 甘肃兰州 730000
5.
河南大学药物研究所,河南开封 475004
6.
河南大学特种功能材料教育部重点实验室, 河南开封 475004

基金项目:

国家自然科学基金项目(51005070)和固体润滑国家重点实验室开放基金(1107)资助.

详细信息

中图分类号: TH117.3
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出版历程
- 收稿日期: 2012-11-12
- 修回日期: 2013-01-17

Formation and Tribological Study of mPEG-b-PLGA Micelles Film

1.
1. The Key Laboratory for Special Functional Materials, Ministry of Education, Henan University, Kaifeng 475004, China
2.
2. State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Lanzhou 730000, China
3.
2. Pharmaceutical College of Henan University, Henan University, Kaifeng 475004, China
4.
3. State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Lanzhou 730000, China
5.
Pharmaceutical College of Henan University, Henan University, Kaifeng 475004, China
6.
The Key Laboratory for Special Functional Materials, Ministry of Education, Henan University, Kaifeng 475004, China

摘要

摘要: 采用层层组装(layer by layer,LBL)方法,以氢键结合方式,将聚乙二醇-b-聚乳酸聚乙醇酸(mPEG-b-PLGA)胶束与聚丙烯酸(PAA)层层交替沉积到硅基底上,分别用接触角测量仪,椭圆偏光测厚仪,X光电子能谱及原子力显微镜等对聚合物胶束自组装薄膜的结构进行了表征,用UMT-2对薄膜的摩擦学特性进行了表征.沉积到基底表面的胶束薄膜能够稳定附着,且具有良好的减摩效果,有望作为导尿管或体内植入器件表面的抗炎、润滑多功能涂层.
- 聚合物胶束 /
- 自组装薄膜 /
- 减摩
Abstract: In this paper, methoxy poly(ethylene glycol)-block-poly(lactic-co-glycolic acid) (mPEG-b-PLGA) micelles and poly(acrylic acid) (PAA) layers were alternately deposited on the silicon substrate, linked by hydrogen bonds. The structure of the micelles films were characterized by contact angle measurements, ellipsometric thickness measurements and X-ray photoelectronic spectroscopy, atomic force microscopy. Anti-wear properties of the films were also evaluated on a ball-on-plate tribometer. It was found that the mPEG-b-of PLGA micelle films were uniformly deposited and offered excellent lubrication. There is a possibility of such thin films as anti-inflaming and lubricating coating used on catheter or device implanted in vivo.
- polymeric micelles /
- self-assembled film /
- lubircating

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参考文献(20)

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