Abstract: The slip behavior between a confined liquid and solid walls subject to planar shearing was investigated using molecular dynamic simulation. Thus a wide range of fluid-solid interaction strength, fluid density, and fluid temperature were simulated in order to find the dominant effects on the slip length between the fluid and the solid wall, which is a key parameter for fluid dynamics. Results indicated that the slip length increased with increasing temperature under a large solid-liquid potential, while it decreased with increasing temperature under a small solid-liquid potential. It was supposed that the structure difference between the neighboring layers of the slippage interface was responsible for the slip behavior.