Abstract: To predict the distribution situation of velocity, pressure, erosion wear in the flushing oil pipeline under typical working condition, the flushing oil pipeline was taken as research object, the Realizable κ-ε turbulent model, stochastic trajectory model and erosion model were utilized in the computational fluid dynamics(CFD) simulation, combining the rotary liquid-solid two phase flow erosion test for corrected erosion wear mathematical model, and the particle erosion damage mechanism of tube wall was analyzed. The results show that the erosion rate of flushing oil pipeline decreased with increasing radius of curvature. The erosion wear in the lateral wall of the bend middle area and the inside wall of the export straight pipe was relatively serious due to the influence of particle inertia and secondary flow in tube, and the orifices in the tee joint reached the maximum. The numerical prediction results agreed well with the anatomical failure case. The quantitative prediction method of erosion wear established in this paper is suitable for risk assessment and life prediction in pressure pipelines.