Abstract: With developing of nano scale science and technology , microtribology is attached moreand more important. It is now one of the most active rescarch area in tribology. It is found that thesystematic operating performance and service life of ultra precision mechanics  or micro mechanicsare determined to a great eatent by friction and wear on nanometer scale , so it is most important tounderstand micro friction and wear. The goal of microtribology is to realize zero wear. The latestdevelopment of researches on micro friction and wear is reviewed in this paper, including thefeatures of micro friction and wear,  experimental methods and results etc . In Addition, theimportant roles of scanning tunnelling microscope (STM) , atomic force micrcocope (AFM) as wellas friction force microscope (FFM) in studying micro friction and wear are introduced anddiscussed. The basic mechanism, applications and new developments of mofecular dynamicssimulation in microtribology are simply introduced. Finally, some suggestions about the furtherstudy on micro friction and wear are proposed.